ABSTRACT
PURPOSE: Of the cancers in childhood, leukemia is the most frequent one. For the desirable control of childhood leukemia, the basic data for the incidence has a great importance. The authors made a report about the incidence of leukemia in childhood, which analyzed the data from 126 cases in Kyongnam province, Korea, during 1991~1995. METHODS: The data were obtained from 126 new cases of childhood leukemia who had been living in the Kyongnam province and were diagnosed at the 26 university hospitals or general hospitals in the Kyongnam area and other cities from 1991 to 1995. RESULTS: The age-and-sex adjusted annual incidence rate per 100,000 population during 1991~1995 varied from 1.82 to 2.86, and cumulative annual incidence rate was 2.41 (male 2.26 and female 2.57 respectively). Male to female sex ratio was 1:1 in total cases. By the major types of childhood leukemia, the cases were composed of acute lymphocytic leukemia 70.6%, acute myelocytic leukemia 26.9% and chronic myelocytic leukemia 2.5%. The cumulative annual incidence rate per 100,000 population (crude rate) during 1991~1995 were 2.77 in Ulsan city, 2.62 in Chinju city and 2.34 in the whole area of Kyongnam province. CONCLUSION: It was concluded that the age-and-sex adjusted annual incidence rate per 100,000 of childhood in Kyongnam province was 2.41, which was lower than that in Pusan city in the same period. And, there was no significant difference of the cumulative annual incidence rate between Ulsan area and Chinju area in the same period.
Subject(s)
Female , Humans , Male , Hospitals, General , Hospitals, University , Incidence , Korea , Leukemia , Leukemia, Myelogenous, Chronic, BCR-ABL Positive , Leukemia, Myeloid, Acute , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Sex RatioABSTRACT
Purposes: Leukemic cells from a significant number of children with acute lymphoblastic leukemia (ALL) express the protein antigens which present the characteristic of both lymphoid and myeloid cells. However the clinical significance of this immunophenotype has remained controversial. In this study, we have retrospectively determined the relationship between the myeloid antigen expression and the outcome after the treatment in the patients of newly diagnosed ALL. METHODS: The total number of one hundred and one newly diagnosed childhood ALL patients, who were admitted to the Department of Pediatrics at Severance Hospital from January 1992 to December 1997 were studied. They were classified as the myeloid antigen positive (My Ag+) and myeloid antigen negative (My Ag-), according to the expression of CD13 and/or CD33 antigens on the surface of leukemic cells. Nineteen patients (19%) among them were myeloid antigen positive. RESULTS: There was no difference between My Ag+ and My Ag- patients in favourable presenting features. The remission rate after induction therapy had no difference between My Ag+ and My Ag- patients. Most of all, there was no difference in 4-year event-free survival (EFS) in both groups. Four year-EFS of My Ag+ patients was 82.2% and that of My Ag- patients was 78.7% (P=0.9). The duration of mean survival rate of My Ag+ patients was 51.1 months and My Ag- patients was 67.8 months. Conclusions: We concluded that there was no difference between MyAg+ ALL and MyAg- ALL patients in the outcome of its treatment. In contrast to previous studies, this result was independent of treatment risk category, demonstrating that myeloid antigen expression was not an adverse prognostic factor for childhood ALL.
Subject(s)
Child , Humans , Disease-Free Survival , Myeloid Cells , Pediatrics , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Prognosis , Retrospective Studies , Sialic Acid Binding Ig-like Lectin 3 , Survival Rate , Treatment OutcomeABSTRACT
PURPOSE: To assess the importance of early clearance of blast cells in peripheral blood and the predictability of outcome in childhood acute lymphoblastic leukemia (ALL) through this method. METHODS: We reviewed medical records of all childhood patients with ALL enrolled on Severance Hospital (January 1992 to December 1997) to determine the presence of blast cells in peripheral blood at diagnosis and after 1 week of intensive induction therapy. RESULTS: Persistent circulating leukemic blasts were present at day 7 in 14 patients (11.4%) among 123 ALL patients. Compared with blast negative group, these patients had two adverse clinical and laboratory features (Hemoglobin level and L2 morphology), and a poorer 4-year event-free survival (69.8% vs. 82.7%, P<0.01). CONCLUSION: We found that this simple and noninvasive method, which can replace bone marrow examination, may be very beneficial to predict the prognosis of ALL.
Subject(s)
Humans , Bone Marrow Examination , Diagnosis , Disease-Free Survival , Drug Therapy , Medical Records , Precursor Cell Lymphoblastic Leukemia-Lymphoma , PrognosisABSTRACT
Most patients with Wilms tumor do not have associated congenital anomalies. However, significant associations with congenital urinary tract defects, hemihypertrophy, and sporadic aniridia have been reported. Horseshoe kidney is a congenital anomaly in which both kidneys are fused at the lower poles with renal parenchymal or fibrous isthmus. The risk of malignancy in a horseshoe kidney is probably not different from that in a normal kidney. But Wilms tumor are more common in patients with horseshoe kidney than in the general population. We report a case of Wilms tumor arising in a horseshoe kidney with brief review of related literatures.
Subject(s)
Humans , Aniridia , Kidney , Urinary Tract , Wilms TumorABSTRACT
The 16 cases of patient with Hodgkin's disease admitted to Department of Pediatrics. Yonsei Cancer Center, Collage of Medicine, Yonsei University during 15 years from January 1975 to December 1989 were reviewed on the basis of clinical charicteristics, treatment and survival rate. The results were summerized as follows. 1) The mean age of patients was 7.6 4.1(range 2~15 years of age). 2) The clinical symptoms and signs were fever (50%), cervical lymphoadenpathy (44%), weight loss(25%), night sweat sweat(19%), hepatomegaly (13%) in order. 3) The stage by Ann Arbor classification revealed Stage I (19%), Stage II (37%), Stage III (19%), stage IV (25%). 4) The histologic subtype of the 14 cases confirmed by Rye Classification revealed that mixed cellularity type (57%) was the most common and lymphocyte predominant type (28%), nodular 5) The seven patients were treated by combind modality therapy, and the six patients by chemotherapy only and the three patients by radiotherapy only. 6) Overall 5 year survival rate was 69% in all patients, and 100% in Stage I, II, 67% in Stage III, but the patients of Stage IV were all died within 7 months.